Contemporary Drug Synthesis Wiley Series On Drug Synthesis.php Book PDF, EPUB Download & Read Online Free

Case Studies in Modern Drug Discovery and Development
Author: Xianhai Huang, Robert G. Aslanian
Publisher: John Wiley & Sons
ISBN: 1118219678
Pages: 472
Year: 2012-04-19
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Learn why some drug discovery and development efforts succeed . . . and others fail Written by international experts in drug discovery and development, this book sets forth carefully researched and analyzed case studies of both successful and failed drug discovery and development efforts, enabling medicinal chemists and pharmaceutical scientists to learn from actual examples. Each case study focuses on a particular drug and therapeutic target, guiding readers through the drug discovery and development process, including drug design rationale, structure-activity relationships, pharmacology, drug metabolism, biology, and clinical studies. Case Studies in Modern Drug Discovery and Development begins with an introductory chapter that puts into perspective the underlying issues facing the pharmaceutical industry and provides insight into future research opportunities. Next, there are fourteen detailed case studies, examining: All phases of drug discovery and development from initial idea to commercialization Some of today's most important and life-saving medications Drugs designed for different therapeutic areas such as cardiovascular disease, infection, inflammation, cancer, metabolic syndrome, and allergies Examples of prodrugs and inhaled drugs Reasons why certain drugs failed to advance to market despite major research investments Each chapter ends with a list of references leading to the primary literature. There are also plenty of tables and illustrations to help readers fully understand key concepts, processes, and technologies. Improving the success rate of the drug discovery and development process is paramount to the pharmaceutical industry. With this book as their guide, readers can learn from both successful and unsuccessful efforts in order to apply tested and proven science and technologies that increase the probability of success for new drug discovery and development projects.
Multicomponent Reactions in Organic Synthesis
Author: Jieping Zhu, Qian Wang, Meixiang Wang
Publisher: John Wiley & Sons
ISBN: 3527332375
Pages: 512
Year: 2015-02-09
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Comprehensive and up–to–date, this book focuses on the latest advances in the field, such as newly developed techniques, more environmentally benign processes, broadened scopes, and completely novel MCRs. In addition to carbene–promoted MCRs and frequently applied metal–catalyzed MCRs, it also covers recently developed catalytic enantioselective variants as well as MCR in drug discovery and for the synthesis of heterocyclic molecules and macrocycles. Edited by the leading experts and with a list of authors reading like a "who′s who" in multicomponent reaction chemistry, this is definitely a must–have for every synthetic organic chemist as well as medicinal chemists working in academia and pharmaceutical companies.
Computer Applications in Pharmaceutical Research and Development
Author: Sean Ekins
Publisher: John Wiley & Sons
ISBN: 0470037229
Pages: 805
Year: 2006-07-11
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A unique, holistic approach covering all functions and phases of pharmaceutical research and development While there are a number of texts dedicated to individual aspects of pharmaceutical research and development, this unique contributed work takes a holistic and integrative approach to the use of computers in all phases of drug discovery, development, and marketing. It explains how applications are used at various stages, including bioinformatics, data mining, predicting human response to drugs, and high-throughput screening. By providing a comprehensive view, the book offers readers a unique framework and systems perspective from which they can devise strategies to thoroughly exploit the use of computers in their organizations during all phases of the discovery and development process. Chapters are organized into the following sections: * Computers in pharmaceutical research and development: a general overview * Understanding diseases: mining complex systems for knowledge * Scientific information handling and enhancing productivity * Computers in drug discovery * Computers in preclinical development * Computers in development decision making, economics, and market analysis * Computers in clinical development * Future applications and future development Each chapter is written by one or more leading experts in the field and carefully edited to ensure a consistent structure and approach throughout the book. Figures are used extensively to illustrate complex concepts and multifaceted processes. References are provided in each chapter to enable readers to continue investigating a particular topic in depth. Finally, tables of software resources are provided in many of the chapters. This is essential reading for IT professionals and scientists in the pharmaceutical industry as well as researchers involved in informatics and ADMET, drug discovery, and technology development. The book's cross-functional, all-phases approach provides a unique opportunity for a holistic analysis and assessment of computer applications in pharmaceutics.
Superbases for Organic Synthesis
Author: Tsutomu Ishikawa
Publisher: John Wiley & Sons
ISBN: 0470740868
Pages: 336
Year: 2009-01-26
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Guanidines, amidines and phosphazenes have been attracting attention in organic synthesis due to their potential functionality resulting from their extremely strong basicity. They are also promising catalysts because of their potential for easy molecular modification, possible recyclability, and reduced or zero toxicity. Importantly, these molecules can be derived as natural products – valuable as scientists move towards “sustainable chemistry”, where reagents and catalysts are derived from biomaterial sources. Superbases for Organic Synthesis is an essential guide to these important molecules for preparative organic synthesis. Topics covered include the following aspects: an introduction to organosuperbases physicochemical properties of organic superbases amidines and guanidines in organic synthesis phosphazene: preparation, reaction and catalytic role polymer-supported organosuperbases application of organosuperbases to total synthesis related organocatalysts: proton sponges and urea derivatives amidines and guanidines in natural products and medicines Superbases for Organic Synthesis is a comprehensive, authoritative and up-to-date guide to these important reagents for organic chemists, drug discovery researchers and those interested in the chemistry of natural products.
Oncology: Breakthroughs in Research and Practice
Author: Management Association, Information Resources
Publisher: IGI Global
ISBN: 1522506381
Pages: 980
Year: 2016-06-29
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Advancements in cancer diagnosis and treatment have extended the lives of many patients facing numerous types of cancer over the years. Research on best practices, new drug development, early identification, and treatment continues to advance with the ultimate goal of uncovering a cure for cancer in all its forms. Oncology: Breakthroughs in Research and Practice features international perspectives on cancer identification, treatment, and management methodologies in addition to patient considerations and outlooks for the future. This collection of emerging research provides valuable insight for researchers, graduate-level students, and professionals in the medical field.
Plant Chemical Biology
Author: Dominique Audenaert, Paul Overvoorde
Publisher: John Wiley & Sons
ISBN: 1118742745
Pages: 312
Year: 2013-11-05
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Demonstrates how advances in plant chemical biology can translate to field applications With contributions from a team of leading researchers and pioneers in the field, this book explains how chemical biology is used as a tool to enhance our understanding of plant biology. Readers are introduced to a variety of chemical biology studies that have provided novel insights into plant physiology and plant cellular processes. Moreover, they will discover that chemical biology not only leads to a better understanding of the underlying mechanisms of plant biology, but also the development of practical applications. For example, the authors discuss small molecules that can be used to identify targets of herbicides and develop new herbicides and plant growth regulators. The book begins with a historical perspective on plant chemical biology. Next, the authors introduce the chemical biology toolbox needed to perform successful studies, with chapters covering: Sources of small molecules Identification of new chemical tools by high-throughput screening (HTS) Use of chemical biology to study plant physiology Use of chemical biology to study plant cellular processes Target identification Translation of plant chemical biology from the lab to the field Based on the latest findings and extensively referenced, the book explores available compound collections, principles of assay design, and the use of new research tools for the development of new applications. Plant Chemical Biology is recommended for students and professionals in all facets of plant biology, including molecular biology, physiology, biochemistry, agriculture, horticulture, and agronomy. All readers will discover new approaches that can lead to the development of a healthier and more plentiful global food supply.
Applied Biocatalysis
Author: Lutz Hilterhaus, Andreas Liese, Ulrich Kettling, Garabed Antranikian
Publisher: John Wiley & Sons
ISBN: 3527677143
Pages: 400
Year: 2016-07-27
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This reference book originates from the interdisciplinary research cooperation between academia and industry. In three distinct parts, latest results from basic research on stable enzymes are explained and brought into context with possible industrial applications. Downstream processing technology as well as biocatalytic and biotechnological production processes from global players display the enormous potential of biocatalysts. Application of "extreme" reaction conditions (i.e. unconventional, such as high temperature, pressure, and pH value) - biocatalysts are normally used within a well defined process window - leads to novel synthetic effects. Both novel enzyme systems and the synthetic routes in which they can be applied are made accessible to the reader. In addition, the complementary innovative process technology under unconventional conditions is highlighted by latest examples from biotech industry.
Antiparasitic and Antibacterial Drug Discovery
Author: Paul M. Selzer
Publisher: John Wiley & Sons
ISBN: 3527323279
Pages: 489
Year: 2009-06-08
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Mainly addressing parasitic diseases but also focusing on diseases caused by bacteria, this much-needed reference and handbook provides a unique insight into the approach adopted by commercial science towards infectious diseases, including the work of medicinal chemists. Many of the authors are scientists with hands-on experience of drug discovery units within the pharmaceutical industry. In addition, the text covers efforts towards drug development in infectious diseases from academic groups and non profit organizations.
The Wiley Handbook of Contextual Behavioral Science
Author: Robert D. Zettle, Steven C. Hayes, Dermot Barnes-Holmes, Anthony Biglan
Publisher: John Wiley & Sons
ISBN: 111848956X
Pages: 568
Year: 2016-01-19
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The Wiley Handbook of Contextual Behavioral Science describes the philosophical and empirical foundation of the contextual behavioral science movement; it explores the history and goals of CBS, explains its core analytic assumptions, and describes Relational Frame Theory as a research and practice program. This is the first thorough examination of the philosophy, basic science, applied science, and applications of Contextual Behavioral Science Brings together the philosophical and empirical contributions that CBS is making to practical efforts to improve human wellbeing Organized and written in such a way that it can be read in its entirety or on a section-by-section basis, allowing readers to choose how deeply they delve into CBS Extensive coverage of this wide ranging and complex area that encompasses both a rich basic experimental tradition and in-depth clinical application of that experimental knowledge Looks at the development of RFT, and its implications for alleviating human suffering
High Society
Author: Mike Jay
Publisher: Simon and Schuster
ISBN: 1620553880
Pages: 192
Year: 2010-10-19
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An illustrated cultural history of drug use from its roots in animal intoxication to its future in designer neurochemicals • Featuring artwork from the upcoming High Society exhibition at the Wellcome Collection in London, one of the world’s greatest medical history collections • Explores the roles drugs play in different cultures as medicines, religious sacraments, status symbols, and coveted trade goods • Reveals how drugs drove the global trade and cultural exchange that made the modern world • Examines the causes of drug prohibitions a century ago and the current “war on drugs” Every society is a high society. Every day people drink coffee on European terraces and kava in Pacific villages; chew betel nut in Indonesian markets and coca leaf on Andean mountainsides; swallow ecstasy tablets in the clubs of Amsterdam and opium pills in the deserts of Rajastan; smoke hashish in Himalayan temples and tobacco and marijuana in every nation on earth. Exploring the spectrum of drug use throughout history--from its roots in animal intoxication to its future in designer neurochemicals--High Society paints vivid portraits of the roles drugs play in different cultures as medicines, religious sacraments, status symbols, and coveted trade goods. From the botanicals of the classical world through the mind-bending self-experiments of 18th- and 19th-century scientists to the synthetic molecules that have transformed our understanding of the brain, Mike Jay reveals how drugs such as tobacco, tea, and opium drove the global trade and cultural exchange that created the modern world and examines the forces that led to the prohibition of opium and cocaine a century ago and the “war on drugs” that rages today.
The Handbook of Drugs and Society
Author: Henry H. Brownstein
Publisher: John Wiley & Sons
ISBN: 1118726790
Pages: 600
Year: 2015-12-07
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This handbook provides a comprehensive examination of the past and present roles of drugs in society with a focus on theory, research, policy, and practice. Includes 28 original chapters with multi-disciplinary and international perspectives by top social and behavioral scientists Reviews current knowledge in the field, including key research findings, theoretical developments, and methodological debates Identifies ongoing controversies in the field, emergent topics, and areas in need of further inquiry Discusses individual drugs as well as topics like physiological theories of drug use and abuse, public health implications of drugs, patterns of drugs and crime, international drug trade and trafficking, and designer drugs
Mass Spectrometry
Author: Edmond de Hoffmann, Vincent Stroobant
Publisher: John Wiley & Sons
ISBN: 1118681940
Pages: 504
Year: 2013-04-03
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The latest edition of a highly successful textbook, Mass Spectrometry, Third Edition provides students with a complete overview of the principles, theories and key applications of modern mass spectrometry. All instrumental aspects of mass spectrometry are clearly and concisely described: sources, analysers and detectors. Tandem mass spectrometry is introduced early on and then developed in more detail in a later chapter. Emphasis is placed throughout the text on optimal utilisation conditions. Various fragmentation patterns are described together with analytical information that derives from the mass spectra. This new edition has been thoroughly revised and updated and has been redesigned to give the book a more contemporary look. As with previous editions it contains numerous examples, references and a series of exercises of increasing difficulty to encourage student understanding. Updates include: Increased coverage of MALDI and ESI, more detailed description of time of flight spectrometers, new material on isotope ratio mass spectrometry, and an expanded range of applications. Mass Spectrometry, Third Edition is an invaluable resource for all undergraduate and postgraduate students using this technique in departments of chemistry, biochemistry, medicine, pharmacology, agriculture, material science and food science. It is also of interest for researchers looking for an overview of the latest techniques and developments.
Structure-based Design of Drugs and Other Bioactive Molecules
Author: Arun K. Ghosh, Sandra Gemma
Publisher: John Wiley & Sons
ISBN: 3527665234
Pages: 474
Year: 2014-07-16
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Drug design is a complex, challenging and innovative research area. Structure-based molecular design has transformed the drug discovery approach in modern medicine. Traditionally, focus has been placed on computational, structural or synthetic methods only in isolation. This one-of-akind guide integrates all three skill sets for a complete picture of contemporary structure-based design. This practical approach provides the tools to develop a high-affinity ligand with drug-like properties for a given drug target for which a high-resolution structure exists. The authors use numerous examples of recently developed drugs to present "best practice" methods in structurebased drug design with both newcomers and practicing researchers in mind. By way of a carefully balanced mix of theoretical background and case studies from medicinal chemistry applications, readers will quickly and efficiently master the basic skills of successful drug design. This book is aimed at new and active medicinal chemists, biochemists, pharmacologists, natural product chemists and those working in drug discovery in the pharmaceutical industry. It is highly recommended as a desk reference to guide students in medicinal and chemical sciences as well as to aid researchers engaged in drug design today.
Practical Methods for Biocatalysis and Biotransformations 3
Author: John Whittall, Peter W. Sutton, Wolfgang Kroutil
Publisher: John Wiley & Sons
ISBN: 1118696298
Pages: 320
Year: 2016-02-16
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Biocatalysts are increasingly used by chemists engaged in fine chemical synthesis within both industry and academia. Today, there exists a huge choice of high-tech enzymes and whole cell biocatalysts, which add enormously to the repertoire of synthetic possibilities. Practical Methods for Biocatalysis and Biotransformations 3 will be a companion book to Practical Methods for Biocatalysis and Biotransformations (2009) and Practical Methods for Biocatalysis and Biotransformations 2 (2012). Following the successful format of the two volumes, it will be a “how-to” guide focusing on commercially available enzymes and strains of microorganisms that are readily obtained from culture collections. The source of starting materials and reagents, hints, tips and safety advice (where appropriate) will be given to ensure, as far as possible, that the procedures are reproducible. Comparisons to alternative methodology will be given and relevant references to the primary literature will be cited. Contents include: Biotransformation Process Technology Industrial Biooxidation Hydrolase catalysed hydrolysis/synthesis Reduction Oxidation Halogenation Transferase catalysed glycosylation, methylation, etc C-C bond formation Tandem Biocatalytic Reactions Practical Methods for Biocatalysis and Biotransformations, Volume 3 is an essential collection of validated biocatalytic methods which will find a place on the bookshelves of synthetic organic chemists, pharmaceutical chemists, and process R&D chemists in industry and academia.
Gene Cloning and DNA Analysis
Author: T. A. Brown
Publisher: John Wiley & Sons
ISBN: 1119072549
Pages: 376
Year: 2015-10-13
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Known world-wide as the standard introductory text to this important and exciting area, the seventh edition of Gene Cloning and DNA Analysis addresses new and growing areas of research whilst retaining the philosophy of the previous editions. Assuming the reader has little prior knowledge of the subject, its importance, the principles of the techniques used and their applications are all carefully laid out, with over 250 clearly presented four-colour illustrations. In addition to a number of informative changes to the text throughout the book, the chapters on DNA sequencing and genome studies have been rewritten to reflect the continuing rapid developments in this area of DNA analysis: In depth description of the next generation sequencing methods and descriptions of their applications in studying genomes and transcriptomes New material on the use of ChiP-seq to locate protein-binding sites Extended coverage of the strategies used to assemble genome sequences Description of how the Neanderthal genome has been sequenced and what that sequence tells us about interbreeding between Neanderthals and Homo sapiens Gene Cloning and DNA Analysis remains an essential introductory text to a wide range of biological sciences students; including genetics and genomics, molecular biology, biochemistry, immunology and applied biology. It is also a perfect introductory text for any professional needing to learn the basics of the subject. All libraries in universities where medical, life and biological sciences are studied and taught should have copies available on their shelves.