Metals And The Skin Topical Effects And Systemic Absorption.php Book PDF, EPUB Download & Read Online Free

Metals and the Skin
Author: Richard H. Guy
Publisher: CRC Press
ISBN: 0824746848
Pages: 448
Year: 1999-04-05
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"Addresses the increase of toxic heavy metals in the environment. Sets the standard for future research in interactions between the skin and metals and metal compounds-covering the general toxicology of 35 metals and metalloids, their occurrence in the environment, significance in nutrition, skin diffusivity, occupational exposure risks, and immunotoxicity."
Percutaneous Penetration Enhancers Drug Penetration Into/Through the Skin
Author: Nina Dragicevic, Howard I. Maibach
Publisher: Springer
ISBN: 3662532700
Pages: 414
Year: 2017-06-01
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Percutaneous Penetration Enhancers in a mini-series format comprising five volumes, represents the most comprehensive reference on enhancement methods – both well established and recently introduced – in the field of dermal/transdermal drug delivery. In detail the broad range of both chemical and physical methods used to enhance the skin delivery of drugs is described. All aspects of drug delivery and measurement of penetration are covered, and the latest findings are provided on skin structure and function, mathematics in skin permeation, and modern analytical techniques adapted to assess and measure penetration. In offering a detailed description of the methods currently in use for penetration enhancement, this book will be of value for researchers, pharmaceutical scientists, practitioners, students and dermatological scientists or dermatologists​.
Occupational skin diseases and dermal exposure in the European Union (EU-25)
Author: European Agency for Safety and Health at Work, Willy De Craecker, Nele Roskams, Rik Op de Beeck
Pages: 107
Year: 2008
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Fluoride in Drinking Water
Author: Committee on Fluoride in Drinking Water, Board on Environmental Studies and Toxicology, Division on Earth and Life Studies, National Research Council
Publisher: National Academies Press
ISBN: 0309657962
Pages: 497
Year: 2007-01-05
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Most people associate fluoride with the practice of intentionally adding fluoride to public drinking water supplies for the prevention of tooth decay. However, fluoride can also enter public water systems from natural sources, including runoff from the weathering of fluoride-containing rocks and soils and leaching from soil into groundwater. Fluoride pollution from various industrial emissions can also contaminate water supplies. In a few areas of the United States fluoride concentrations in water are much higher than normal, mostly from natural sources. Fluoride is one of the drinking water contaminants regulated by the U.S. Environmental Protection Agency (EPA) because it can occur at these toxic levels. In 1986, the EPA established a maximum allowable concentration for fluoride in drinking water of 4 milligrams per liter, a guideline designed to prevent the public from being exposed to harmful levels of fluoride. Fluoride in Drinking Water reviews research on various health effects from exposure to fluoride, including studies conducted in the last 10 years.
Nickel and the Skin
Author: Howard I. Maibach, Torkil Menne
Publisher: CRC Press
ISBN: 0849369762
Pages: 232
Year: 1989-04-30
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This publication serves as a guide to medical doctors and dentists in the evaluation and management of problems related to nickel allergy. The chemistry, analysis, and monitoring of nickel is explored. Recent advances in the immunology of nickel are dis-cussed. Additionally, sensitization assays for both humans and animals are presented. The clinical, genetic, and epidemiologic as-pects of nickel sensitization and nickel dermatitis are explained. Social and demographic aspects of nickel contact allergy are dis-cussed, as well as the topic of the nickel dermatitis as a pre-ventable health problem.
Transdermal Magnesium Therapy
Author: Dr. Mark Sircus
Publisher: Lulu Press, Inc
ISBN: 1312528451
Year: 2014-09-17
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This book has the potential to save your life. Magnesium has been used around the world to bring people back from the brink of death and Dr Mark Sircus examines how this amazing mineral that is so overlooked by the majority affects so many aspects of our health including cancer, heart disease, diabetes, depression, asthma, inflammation, arthritis and autism.
Veterans at Risk
Author: Constance M. Pechura, David P. Rall
Publisher: National Academies
Pages: 427
Year: 1993
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Recently, World War II veterans have come forward to claim compensation for health effects they say were caused by their participation in chemical warfare experiments. This new volume discusses in detail the development and chemistry of mustard agents and Lewisite followed by interesting and informative discussions about these substances and their possible connection to a range of health problems, from cancer to reproductive disorders. Index.
Topical and Transdermal Drug Delivery
Author: Heather A. E. Benson, Adam C. Watkinson
Publisher: John Wiley & Sons
ISBN: 1118140494
Pages: 432
Year: 2012-02-03
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Practical drug development approaches presented by leading experts Designed to support the development of new, effective therapeutics, Topical and Transdermal Drug Delivery: Principles and Practice explains the principles underlying the field and then demonstrates how these principles are put into practice in the design and development of new drug products. Drawing together and reviewing the latest research findings, the book focuses on practical, tested, and proven approaches that are backed by industry case studies and the authors' firsthand experience. Moreover, the book emphasizes the mechanistic information that is essential for successful drug product development. Topical and Transdermal Drug Delivery: Principles and Practice is divided into two parts: Part One, Current Science, Skin Permeation, and Enhancement Approaches, offers readers a fundamental understanding of the underlying science in the field. It describes the principles and techniques needed to successfully perform experimental approaches, covering such issues as skin permeation, enhancement, and assessment. Part Two, Topical and Transdermal Product Development, guides readers through the complete product development process from concept to approval, offering practical tips and cautions from experts in the field. This part also discusses regulations that are specific to the development of dermal drug products. The final chapter explores current and future trends, forecasting new development techniques and therapeutics. Throughout the book, the authors clearly set forth the basic science and experimental procedures, making it possible for researchers to design their own experimental approaches and accurately interpret their results. With contributions from experienced drug researchers, this text is highly recommended for all researchers involved in topical and transdermal product development who need to know both the state of the science and the standards of practice.
Principles and Practice of Skin Toxicology
Author: Robert Chilcott, Shirley Price
Publisher: John Wiley & Sons
ISBN: 0470773081
Pages: 392
Year: 2008-07-31
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Written by authorities in the field, this book provides a “bottom up” approach to studying skin toxicology. Principles and Practice of Skin Toxicology clearly outlines basic concepts, cites historical and modern references and contains a dictionary for easy reference. The inclusion of global legislation and regulatory aspects on the topic makes this a comprehensive review for every practitioner, clinical researcher in industry and academia, and MSc and PhD student of toxicology. Different sections cover skin structure and function, principles and measurement of skin absorption, clinical aspects of dermal toxicity and in vitro alternatives. A section on regulatory and legislative aspects includes case studies from the UK that fulfill European Union and US FDA requirements. A glossary provides definitions of technical terms, and the chapters contain an introduction, learning boxes and summary section for ease of use. Includes a chapter on drug delivery through the skin. Addresses risk assessment: a key area for the interpretation of skin absorption data that is rarely covered.
Hydrogen Cyanide and Cyanides
ISBN: 9241530618
Pages: 67
Year: 2004
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Author: Edward Sagarin
Pages: 1433
Year: 1957
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Applied Pharmacokinetics
Author: William E. Evans, Jerome J. Schentag, William J. Jusko
Publisher: Applied Therapeutics, Incorporated
ISBN: 0915486156
Pages: 1202
Year: 1992-01-01
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The Third Edition of Applied Pharmacokinetics remains the gold standard by which all other clinical pharmacokinetics texts are measured. Written by leading pharmacokinetics researchers and practitioners, this book is the most advanced kinetics reference available. All chapters have been extensively updated or completely rewritten for this edition, and six new chapters have been added on pharmacodynamics, pharmacogenetics, pharmacokinetic considerations in the obese, dietary influences on drug disposition, zidovudine, and corticosteroids. Each chapter is tightly focused on the most important concepts and issues. Chapters on specific drugs are organized in a consistent format for quick, easy information retrieval. Major subheadings include Clinical Pharmacokinetics, Pharmacodynamics, Clinical Application of Pharmacokinetic Data, Analytical Methods, and Prospectus.
Handbook of Pharmaceutical Excipients
Author: Raymond C. Rowe, Paul J. Sheskey, Marian E. Quinn
Publisher: Amer Pharmacists Assn
ISBN: 1582121354
Pages: 888
Year: 2009-01-01
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An internationally acclaimed reference work recognized as one of the most authoritative and comprehensive sources of information on excipients used in pharmaceutical formulation with this new edition providing 340 excipient monographs. Incorporates information on the uses, and chemical and physical properties of excipients systematically collated from a variety of international sources including: pharmacopeias, patents, primary and secondary literature, websites, and manufacturers' data; extensive data provided on the applications, licensing, and safety of excipients; comprehensively cross-referenced and indexed, with many additional excipients described as related substances and an international supplier's directory and detailed information on trade names and specific grades or types of excipients commercially available.
Author: Nicola Fabris
Publisher: Springer Science & Business Media
ISBN: 1468445472
Pages: 478
Year: 2012-12-06
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Immunoregulation is one of the areas which has witnessed the most explosive advances of immunology during the past decade. It is in this area that the current view of the immune system has arisen and developed. There is indeed little doubt that immune reactions are primarily determined by messages which are genera ted within the immune system and passed among different types of immunologie cells. This cell communication not only determines the type, intensity and duration of the response after perturbation of the immune system by exogenous antigens, but it is also essential for preventing autoimmune reactions and their clinical conse quences. In order to assure aperfect balance within the enormous com plexity of the immune system, it is not surprising that multiple self-regulatory mechanisms are organized at different levels, such as antibody feedback, idiotypic-anti-idiotypic responses, suppres sor and helper T cells, lymphokine signals and genetic require ments. A nu mb er of observations in recent years have, however, demonstrated that consistent contributions to the immunological homeostasis are given also by signals generated outside of the immune system, namely,in the central and autonomous nervous system as weIl as in the endocrine apparatus. Furthermore, the interactions between the immune system and the other body homestatic mechanisms seem to be bidirectional: if immunological cells may be targets of neuroendocrinological factors, immunological products seem in turn to contribute to the neuro endocrine homeostasis.
Metal Allergy
Author: Jennifer K Chen, Jacob P. Thyssen
Publisher: Springer
ISBN: 3319585037
Pages: 578
Year: 2018-04-13
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This volume opens by providing a comprehensive overview of the use and regulation of metals in our society, metal properties, and available testing methodologies. Common and uncommon metal allergens and sources of exposure are then reviewed in depth, detailing allergic responses and paying special consideration to select patient populations. In the general population, the prevalence of metal allergy is high. Environmental sources of metal exposure include jewelry, clothing, electronic devices, coins, leather, diet, and occupational exposure. Metal allergy may result in allergic contact dermatitis and systemic contact dermatitis, as well as several less common manifestations. Further, metal allergy has been associated with device failure and/or dermatitis following implantation of medical devices and dental implants. As metals are ubiquitous, this book will be indispensable for a wide range of clinicians and investigators. This handy reference will meet the needs of all health professionals and investigators who are interested in metal allergy and its diagnosis and management.