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Research Advances in Rabies
Author:
Publisher: Academic Press
ISBN: 0123870410
Pages: 486
Year: 2011-07-13
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Volume 79 of Advances in Virus Research focuses on developments surrounding rabies, an ancient disease that remains a prominent public health problem for humans. This volume highlights important research advances extending from our understanding of how the rabies virus replicates and assembles to how the disease can be prevented and treated in humans and how rabies can be controlled in wildlife hosts. Experts in the field provide insightful and up-to-date chapters that summarize our current state of knowledge in diverse aspects of this very interesting and important viral disease. Contributions from leading authorities and industry experts Informs and updates on all the latest developments in the field
WHO Expert Consultation on Rabies
Author: World Health Organization
Publisher: World Health Organization
ISBN: 9241209828
Pages: 139
Year: 2013
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"Although there is debate about the estimated health burden of rabies, the estimates of direct mortality and the DALYs due to rabies are among the highest of the neglected tropical diseases. Poor surveillance, underreporting in many developing countries, frequent misdiagnosis of rabies, and an absence of coordination among all the sectors involved are likely to lead to underestimation of the scale of the disease It is clear, however, that rabies disproportionately affects poor rural communities, and particularly children. Most of the expenditure for post- exposure prophylaxis is borne by those who can least afford it. As a result of growing dog and human populations, the burden of human deaths from rabies and the economic costs will continue to escalate in the absence of concerted efforts and investment for control. Since the first WHO Expert Consultation on Rabies in 2004, WHO and its network of collaborating centres on rabies, specialized national institutions, members of the WHO Expert Advisory Panel on Rabies and partners such as the Gates Foundation, the Global Alliance for Rabies Control and the Partnership for Rabies Prevention, have been advocating the feasibility of rabies elimination regionally and globally and promoting research into sustainable cost-effective strategies. Those joint efforts have begun to break the cycle of rabies neglect, and rabies is becoming recognized as a priority for investment. This Consultation concluded that human dog-transmitted rabies is readily amenable to control, regional elimination in the medium term and even global elimination in the long term. A resolution on major neglected tropical diseases, including rabies, prepared for submission to the World Health Assembly in May 2013 aims at securing Member States' commitment to the control, elimination or eradication of these diseases. Endorsement of the resolution would open the door for exciting advances in rabies prevention and control."--Publisher's description.
Neurovirology: Viruses and the Brain
Author:
Publisher: Elsevier
ISBN: 0080493807
Pages: 645
Year: 2001-07-06
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This volume is the first in a planned series of thematic volumes for Advances in Virus Research. It covers the etiology, pathogenetic mechanisms, and clincial consequences of human neurotropic viruses. Buchmeier is a virologist, Campbell an immunologist, and both are extremely well known in their fields. Numerous illustrations including colour Knowledgeable discussion of the potential role of viral infections in teratogenic and developmental disorders Frank discussion of the role of stress in disease Behavioural consequences of chronic CNS infection
Infectious Diseases of the Dog and Cat - E-Book
Author: Craig E. Greene
Publisher: Elsevier Health Sciences
ISBN: 0323266215
Pages: 1376
Year: 2013-09-27
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The definitive reference for the diagnosis, treatment, and prevention of small animal infections, Infectious Diseases of the Dog and Cat, 4th Edition delivers current, comprehensive information essential to the management of infectious diseases caused by viruses, rickettsiae, chlamydiae, mycoplasmas, bacteria, fungi, algae, protozoa, and unknown agents. Each section guides you through diagnostic testing for specific microorganisms, from sample collection to laboratory submission to interpretation of results, then details appropriate treatment measures and pharmacologic considerations for the various related infections. Full-color illustrations and hundreds of tables provide quick, convenient access to diagnostic and therapeutic guidelines, and thoroughly updated drug information helps you confidently administer appropriate dosages for the most effective treatment and prevention. The most comprehensive infectious disease coverage available helps you confidently address clinical problems related to infectious diseases in dogs and cats, and includes: Immunization strategies and environmental control of infections Immunodeficiency disorders Prevention of infection in multi-pet and shelter settings Immunocompromised people and their pets Vibrant full-color illustrations clarify disease features and modes of disease transmission for enhanced diagnostic accuracy and disease prevention. Convenient tables deliver therapeutic recommendations and drug dosages at a glance. Complete antimicrobial drug formulary provides fast, easy access to indications, recommended dosages, and pharmacologic considerations essential for all relevant pharmaceuticals. State-of-the-art diagnostic testing procedures help you ensure accurate diagnoses for all clinically relevant pathogens. Content reflects the expert insight and vast clinical experience of a panel of trusted authorities on small animal infectious diseases. Easy-to-use companion website provides convenient online access to additional images, tables, boxes, appendices, and references linked directly to original PubMed abstracts. Expanded coverage of zoonoses, zoonotic potential, and precautions helps you effectively monitor and treat zoonotic infections. Fully updated drug formulary reflects the most current pharmacokinetics, indications, contraindications, handling and administration guidelines, and dosage recommendations available. Updated content throughout the text details current diagnostic testing regimens and therapeutic and preventive considerations for all pathogens you're likely to encounter in the clinical setting. Special focus on disease incidence and susceptibility in traveling animals helps you alert animal owners to potential risks associated with pet travel.
Rabies in the Tropics
Author: E. Kuwert, C. Merieux, H. Koprowski, Konrad Bögel
Publisher: Springer Science & Business Media
ISBN: 3642700608
Pages: 786
Year: 2012-12-06
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Rabies-as in former times-is still today a major killer affecting man and animals especially in many tropical and sub-tropical countries of Asia, Africa and South America. Some 50,000 people and literally millions of animals suffer and die of this disease each year. This dramatic death toll and the enormous economic losses which ensue are nowadays un tolerable and no longer justified. Worldwide strategy for Rabies control has been established and the World Health Organization recently formulated an elimination programme for dog Rabies. Methods for wildlife Rabies control are also under way. For the realisation of control campaigns, careful epid emiological analysis is necessary. This involves: - antigenical characterisation of Rabies Virus Strains using monoclonal antibodies, - observation of foci, - follow-up of the front wave of the disease, - specific ecology of target populations and Rabies carrier species. The financial point of view of such campaigns has of course to be ascertained. It is for the first time ever that representatives and specialists of different biological disciplines from nearly 70 countries have had the opportunity in Tunis to discuss these important issues and to evaluate, on the basis of their own experimental results and personal epidemiological observations, the possibility of ultimate elimination of Rabies in tropical and sub-tropical countries and also to contribute their share for a better understanding of the natural history of this disease.
Toward Precision Medicine:
Author: Committee on a Framework for Development a New Taxonomy of Disease, Board on Life Sciences, Division on Earth and Life Studies, National Research Council
Publisher: National Academies Press
ISBN: 0309222222
Pages: 142
Year: 2011-12-16
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Motivated by the explosion of molecular data on humans-particularly data associated with individual patients-and the sense that there are large, as-yet-untapped opportunities to use this data to improve health outcomes, Toward Precision Medicine explores the feasibility and need for "a new taxonomy of human disease based on molecular biology" and develops a potential framework for creating one. The book says that a new data network that integrates emerging research on the molecular makeup of diseases with clinical data on individual patients could drive the development of a more accurate classification of diseases and ultimately enhance diagnosis and treatment. The "new taxonomy" that emerges would define diseases by their underlying molecular causes and other factors in addition to their traditional physical signs and symptoms. The book adds that the new data network could also improve biomedical research by enabling scientists to access patients' information during treatment while still protecting their rights. This would allow the marriage of molecular research and clinical data at the point of care, as opposed to research information continuing to reside primarily in academia. Toward Precision Medicine notes that moving toward individualized medicine requires that researchers and health care providers have access to very large sets of health- and disease-related data linked to individual patients. These data are also critical for developing the information commons, the knowledge network of disease, and ultimately the new taxonomy.
Reaching Students:
Author: Nancy Kober, Board on Science Education, Division on Behavioral and Social Sciences and Education, National Research Council
Publisher: National Academies Press
ISBN: 0309300460
Pages: 256
Year: 2015-01-15
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The undergraduate years are a turning point in producing scientifically literate citizens and future scientists and engineers. Evidence from research about how students learn science and engineering shows that teaching strategies that motivate and engage students will improve their learning. So how do students best learn science and engineering? Are there ways of thinking that hinder or help their learning process? Which teaching strategies are most effective in developing their knowledge and skills? And how can practitioners apply these strategies to their own courses or suggest new approaches within their departments or institutions? Reaching Students strives to answer these questions. Reaching Students presents the best thinking to date on teaching and learning undergraduate science and engineering. Focusing on the disciplines of astronomy, biology, chemistry, engineering, geosciences, and physics, this book is an introduction to strategies to try in your classroom or institution. Concrete examples and case studies illustrate how experienced instructors and leaders have applied evidence-based approaches to address student needs, encouraged the use of effective techniques within a department or an institution, and addressed the challenges that arose along the way. The research-based strategies in Reaching Students can be adopted or adapted by instructors and leaders in all types of public or private higher education institutions. They are designed to work in introductory and upper-level courses, small and large classes, lectures and labs, and courses for majors and non-majors. And these approaches are feasible for practitioners of all experience levels who are open to incorporating ideas from research and reflecting on their teaching practices. This book is an essential resource for enriching instruction and better educating students.
The Politically Incorrect Guide to Science
Author: Tom Bethell
Publisher: Simon and Schuster
ISBN: 1596986301
Pages: 270
Year: 2005-11-25
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"If the globe is warming, is mankind responsible, or is the sun?" Such a statement does not appear out of place in Bethell's entertaining account of how modern science is politically motivated and in desperate need of oversight. Bethell writes in a compulsively readable style, and although he provides legitimate insight into the potential benefits of nuclear power and hormesis, some readers will be turned off when he attempts to disprove global warming and especially evolution. Throughout the book, Bethell makes questionable claims about subjects as varied as AIDS ("careful U.S. studies had already shown that at least a thousand sexual contacts are needed to achieve heterosexual transmission of the virus") and extinction ("It is not possible definitely to attribute any given extinction to human activity"), and backs up his arguments with references to the music magazine SPIN and thriller-writer Michael Crichton. Ironically, Bethell ends up proving his own premise by producing a highly politicized account of how liberal intellectuals and unchecked government agencies have created a "white-coated priesthood" whose lust for grant money has driven them to produce fearsome (but in Bethell's view, false) tales of ozone destruction and AIDS pandemics. In the end, this book is unlikely to sway readers who aren't already in Bethell's ideological camp, as any points worthy of discussion get lost in the glut of unsourced claims that populate this latest installment of "The Politically Incorrect Guide" series.
Human Virology in Latin America
Author: Juan Ernesto Ludert, Flor H. Pujol, Juan Arbiza
Publisher: Springer
ISBN: 3319545671
Pages: 474
Year: 2017-07-19
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This book is a compilation of some of the most remarkable contributions made by scientists currently working in Latin America to the understanding of virus biology, the pathogenesis of virus-related diseases, virus epidemiology, vaccine trials and antivirals development. In addition to recognizing the many fine virologists working in Latin America, Human Virology in Latin America also discusses both the state-of-the-art research and the current challenges that are being faced in the region, in hopes of inspiring young scientists worldwide to become eminent virologists.
The Emergence of Zoonotic Diseases
Author: Institute of Medicine, Board on Global Health, Forum on Emerging Infections
Publisher: National Academies Press
ISBN: 0309169739
Pages: 176
Year: 2002-04-09
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Zoonotic diseases represent one of the leading causes of illness and death from infectious disease. Defined by the World Health Organization, zoonoses are “those diseases and infections that are naturally transmitted between vertebrate animals and man with or without an arthropod intermediate.†Worldwide, zoonotic diseases have a negative impact on commerce, travel, and economies. In most developing countries, zoonotic diseases are among those diseases that contribute significantly to an already overly burdened public health system. In industrialized nations, zoonotic diseases are of particular concern for at-risk groups such as the elderly, children, childbearing women, and immunocompromised individuals. The Emergence of Zoonotic Diseases: Understanding the Impact on Animal and Human Health, covers a range of topics, which include: an evaluation of the relative importance of zoonotic diseases against the overall backdrop of emerging infections; research findings related to the current state of our understanding of zoonotic diseases; surveillance and response strategies to detect, prevent, and mitigate the impact of zoonotic diseases on human health; and information about ongoing programs and actions being taken to identify the most important needs in this vital area.
Globalization, Biosecurity, and the Future of the Life Sciences
Author: National Research Council, Institute of Medicine, Board on Global Health, Policy and Global Affairs, Development, Security, and Cooperation, Committee on Advances in Technology and the Prevention of Their Application to Next Generation Biowarfare Threats
Publisher: National Academies Press
ISBN: 0309164753
Pages: 316
Year: 2006-06-07
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Biomedical advances have made it possible to identify and manipulate features of living organisms in useful ways--leading to improvements in public health, agriculture, and other areas. The globalization of scientific and technical expertise also means that many scientists and other individuals around the world are generating breakthroughs in the life sciences and related technologies. The risks posed by bioterrorism and the proliferation of biological weapons capabilities have increased concern about how the rapid advances in genetic engineering and biotechnology could enable the production of biological weapons with unique and unpredictable characteristics. Globalization, Biosecurity, and the Future of Life Sciences examines current trends and future objectives of research in public health, life sciences, and biomedical science that contain applications relevant to developments in biological weapons 5 to 10 years into the future and ways to anticipate, identify, and mitigate these dangers.
Biology and Pathogenesis of Rhabdo- and Filoviruses
Author: Asit K Pattnaik, Michael A Whitt
Publisher: World Scientific
ISBN: 9814635359
Pages: 640
Year: 2014-12-30
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Rhabdoviruses and Filoviruses are single-stranded, non-segmented, negative-strand RNA viruses, many of which cause significant morbidity and mortality in humans and animals. Certain members of these virus families have been used as excellent model systems to understand the molecular biology of replication, host responses to infections, and viral countermeasures. Rhabdoviruses have also been used as vaccine vectors as well as oncolytic agents. Studies on Filoviruses have now provided significant insights into how they enter susceptible cells, replicate and cause disease, and also how they evade the host's immune mechanisms. This book addresses the most recent findings on Rhabdovirus and Filovirus structure, replication mechanisms, host cell responses to virus infections and viral countermeasures. Chapters on emerging viruses as well as approaches for therapeutic interventions have also been included. This book represents an authoritative text that brings together the most recent advances on the cellular and molecular biology of Rhabdo- and Filoviruses, including mechanisms of pathogenesis. Contents:Overview of Rhabdo– and Filoviruses (Asit K Pattnaik and Michael A Whitt)Rhabdovirus Structure (Ming Luo)The Pathway of VSV Entry into Cells (Shem Johnson and Jean Gruenberg)Rhabdovirus Glycoproteins (Yves Gaudin and Michael A Whitt)VSV RNA Transcription and Replication (Jacques Perrault)Host Cell Functions in Vesicular Stomatitis Virus Replication (Phat X Dinh, Anshuman Das, and Asit K Pattnaik)Cytopathogenesis of Rhabdoviruses (Douglas S Lyles)Assembly and Budding of Rhabdo– and Filoviruses (Ziying Han and Ronald N Harty)Rhabdoviruses as Vaccine Vectors: From Initial Development to Clinical Trials (John K Rose and David K Clarke)Oncolytic Rhabdoviruses (Nicole E Forbes and John C Bell)Use of Rhabdoviruses to Study Neural Circuitry (Melanie Ginger, Guillaume Bony, Matthias Haberl, and Andreas Frick)Evolution of Rhabdo– and Filoviruses (Isabel S Novella, John B Presloid, and R Travis Taylor)Emerging Rhabdoviruses (Imke Steffen and Graham Simmons)Rabies Virus Replication and Pathogenesis (Andrew W Hudacek and Matthias J Schnell)Activation and Evasion of Innate Immune Response by Rhabdoviruses (Karl-Klaus Conzelmann)Rabies Virus Vaccines (Ying Huang, Clement W Gnanadurai, and Zhen F Fu)Filovirus Structure and Morphogenesis (Timothy F Booth, Daniel R Beniac, Melissa J Rabb, and Lindsey L Lamboo)Epidemiology and Pathogenesis of Filovirus Infections (Logan Banadyga and Hideki Ebihara)Filovirus Entry into Susceptible Cells (Rohit K Jangra, Eva Mittler, and Kartik Chandran)Filovirus Transcription & Replication (Kristina Brauburger, Laure R Deflubé, and Elke Muhlberger)Innate Immune Evasion Mechanisms of Filoviruses (Christopher F Basler, Gaya K Amarasinghe, and Daisy W Leung)Vaccines and Antivirals for Filoviruses (Chad E Mire and Thomas W Geisbe) Readership: Investigators, graduate students, and post-graduate researchers in the field of RNA virology. Key Features:The book describes the most recent advances in our understanding of cellular and molecular aspects of replication and pathogenic mechanisms of these two important viral pathogensUnlike other existing textbooks published earlier, this book brings together several major topics of research such as replication, host response to viral replication and viral countermeasures, viral evolution and emerging viruses, viral vectors, vaccines and antivirals, etcThe chapters in the book are written by renowned researchers in these fieldsKeywords:Negative-Strand RNA Virus;Mononegavirales;Rhabdovirus;Filovirus;VSV;Rabies Virus;Marburg Virus;Ebola Virus;Replication and Transcription;Virus Structure;Viral Pathogenesis;Epidemiology;Virus Entry;Virus Assembly and Budding;Cytopathogenesis;Neuronal Tracers;Viral Vectors;Oncolytic Viruses;Evolution;Emerging Viruses;Innate Immune Responses;Vaccines;Antivirals
Virology
Author: John Carter, Venetia A. Saunders
Publisher: John Wiley & Sons
ISBN: 0470023864
Pages: 358
Year: 2007-08-15
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Virology is a clear and accessible introduction to this fast moving field, providing a comprehensive resource enabling students to understand the key concepts surrounding this exciting subject. The authors have produced a text that stimulates and encourages the student through the extensive use of clear, colour-coded diagrams. Taking a modern approach to the subject, the relevance of virology to everyday life is clearly emphasised and discussion on emerging viruses, cancer, vaccines, anti-viral drugs gene vectors and pesticides is included. This title: Provides an introduction to the theories behind the origins of viruses and how they are evolving with discussion on emerging viruses Includes numerous diagrams with standard colour coding for different types of molecule such as DNA, messenger RNA, other virus RNA’s proteins – all diagrams are carefully developed and clearly labelled to enhance student understanding Features self-contained descriptions of the complete replication cycles of a selection of viruses Introduces the relevance of virology to the modern world including the latest developments in the field - HIV, Foot and Mouth disease, Ebola, SARS and MMR Presents summary boxes, further reading and an associated website to include the latest developments Virology is an essential textbook for all undergraduate students of biology, microbiology and biomedical sciences taking courses in virology. It is also an invaluable resource for MSc level students who have previously done little or no virology and are looking for an accessible introduction to the subject.
Rhabdoviruses
Author: Ralf Georg Dietzgen, Ivan V. Kuzmin
Publisher: Horizon Scientific Press
ISBN: 1908230118
Pages: 276
Year: 2012
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Rhabdoviruses are a diverse family of single stranded, negative sense RNA viruses that can successfully utilize a myriad of ecological niches, ranging from plants and insects to fish and mammals. This virus family includes pathogens, such as rabies virus, vesicular stomatitis virus, and potato yellow dwarf virus that are of tremendous public health, veterinary, and agricultural significance. Due to the relative simplicity of their genomes and morphology, in recent years rhabdoviruses have become powerful model systems for studying molecular virology. Written by a select group of world-renowned virologists, this book reviews all of the most recent advances in rhabdovirology, providing a timely overview of the field. Most contributions are written from a molecular and genomic perspective and contain expert insights upon which to base future research efforts. The topics covered include: morphology * genome organization * transcription * virus replication * taxonomy * characterization * virus evolution * vesiculovirus * lyssavirus * ephemeroviruses * fish novirhabdoviruses * the sigma viruses of Drosophila * virus-host protein interaction of plant-adapted rhabdoviruses * cereal-infecting rhabdoviruses * rabies prevention and control, including lyssavirus vaccine development. The book is a "must read" for all virologists working on these and related negative sense RNA viruses. It is recommended for all biology, veterinary, and medical libraries.
Guidelines for the Treatment of Malaria. Third Edition
Author: World Health Organization
Publisher: World Health Organization
ISBN: 9241549122
Pages: 313
Year: 2015-08-13
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Malaria remains an important cause of illness and death in children and adults in countries in which it is endemic. Malaria control requires an integrated approach including prevention (primarily vector control) and prompt treatment with effective antimalarial agents. Malaria case management consisting of prompt diagnosis and effective treatment remains a vital component of malaria control and elimination strategies. Since the publication of the first edition of the Guidelines for the treatment of malaria in 2006 and the second edition in 2010 all countries in which P. falciparum malaria is endemic have progressively updated their treatment policy from use of ineffective monotherapy to the currently recommended artemisinin-based combination therapies (ACT). This has contributed substantially to current reductions in global morbidity and mortality from malaria. Unfortunately resistance to artemisinins has arisen recently in P. falciparum in South-East Asia which threatens these gains. This third edition of the WHO Guidelines for the treatment of malaria contains updated recommendations based on a firmer evidence base for most antimalarial drugs and in addition include recommendation on the use of drugs to prevent malaria in groups at high risk. The Guidelines provide a framework for designing specific detailed national treatment protocols taking into account local patterns of resistance to antimalarial drugs and health service capacity. It provides recommendations on treatment of uncomplicated and severe malaria in all age groups all endemic areas in special populations and several complex situations. In addition on the use of antimalarial drugs as preventive therapy in healthy people living in malaria-endemic areas who are high risk in order to reduce morbidity and mortality from malaria. The Guidelines are designed primarily for policy-makers in ministries of health who formulate country-specific treatment guidelines. Other groups that may find them useful include health professionals and public health and policy specialists that are partners in health or malaria control and the pharmaceutical industry. The treatment recommendations in the main document are brief; for those who wish to study the evidence base in more detail a series of annexes is provided with references to the appropriate sections of the main document.