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Synthetic Biology
Author: Markus Schmidt
Publisher: John Wiley & Sons
ISBN: 3527659277
Pages: 266
Year: 2012-05-14
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This is the only book to focus on industrial and environmental applications of synthetic biology, covering 17 of the most promising uses in the areas of biofuel, bioremediation and biomaterials. The contributions are written by experts from academia, non-profit organizations and industry, outlining not only the scientific basics but also the economic, environmental and ethical impact of the new technologies. This makes it not only suitable as supplementary material for students but also the perfect companion for policy makers and funding agencies, if they are to make informed decisions about synthetic biology. Largely coordinated by Markus Schmidt, a policy adviser, and the only European to testify in front of the bioethics commission of the Obama administration.
Positioning Synthetic Biology to Meet the Challenges of the 21st Century
Author: Committee on Science, Technology, and Law, Policy and Global Affairs, Board on Life Sciences, Division on Earth and Life Studies, National Academy of Engineering, National Research Council
Publisher: National Academies Press
ISBN: 0309225841
Pages: 59
Year: 2013-08-19
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Synthetic biology -- unlike any research discipline that precedes it -- has the potential to bypass the less predictable process of evolution to usher in a new and dynamic way of working with living systems. Ultimately, synthetic biologists hope to design and build engineered biological systems with capabilities that do not exist in natural systems -- capabilities that may ultimately be used for applications in manufacturing, food production, and global health. Importantly, synthetic biology represents an area of science and engineering that raises technical, ethical, regulatory, security, biosafety, intellectual property, and other issues that will be resolved differently in different parts of the world. As a better understanding of the global synthetic biology landscape could lead to tremendous benefits, six academies -- the United Kingdom's Royal Society and Royal Academy of Engineering, the United States' National Academy of Sciences and National Academy of Engineering, and the Chinese Academy of Science and Chinese Academy of Engineering -- organized a series of international symposia on the scientific, technical, and policy issues associated with synthetic biology. Positioning Synthetic Biology to Meet the Challenges of the 21st Century summarizes the symposia proceedings.
Absence in Science, Security and Policy
Author: Brian Balmer, Brian Rappert
Publisher: Springer
ISBN: 1137493739
Pages: 240
Year: 2016-02-06
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This book explores the absent and missing in debates about science and security. Through varied case studies, including biological and chemical weapons control, science journalism, nanotechnology research and neuroethics, the contributors explore how matters become absent, ignored or forgotten and the implications for ethics, policy and society.
Synthetic Biology and Morality
Author: Gregory E. Kaebnick, Thomas H. Murray
Publisher: MIT Press
ISBN: 0262519593
Pages: 214
Year: 2013-07-26
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A range of views on the morality of synthetic biology and its place in public policy and political discourse.
Information and Communication Technologies in Education, Research, and Industrial Applications
Author: Vadim Ermolayev, Heinrich C. Mayr, Mykola Nikitchenko, Aleksander Spivakovsky, Grygoriy Zholtkevych
Publisher: Springer
ISBN: 3319132067
Pages: 371
Year: 2014-11-27
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This book constitutes the thoroughly refereed proceedings of the 10th International Conference on Information and Communication Technologies in Education, Research, and Industrial Applications, held in Kherson, Ukraine, in June 2014. The 16 revised full papers presented were carefully reviewed and selected from 66 submissions. The papers are organized in topical sections on framework and tools; information and communication technologies in teaching and learning; information and communication technologies in research and industrial applications.
The Science and Applications of Synthetic and Systems Biology:
Author: Forum on Microbial Threats, Board on Global Health, Institute of Medicine
Publisher: National Academies Press
ISBN: 0309219396
Pages: 568
Year: 2011-11-30
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Many potential applications of synthetic and systems biology are relevant to the challenges associated with the detection, surveillance, and responses to emerging and re-emerging infectious diseases. On March 14 and 15, 2011, the Institute of Medicine's (IOM's) Forum on Microbial Threats convened a public workshop in Washington, DC, to explore the current state of the science of synthetic biology, including its dependency on systems biology; discussed the different approaches that scientists are taking to engineer, or reengineer, biological systems; and discussed how the tools and approaches of synthetic and systems biology were being applied to mitigate the risks associated with emerging infectious diseases. The Science and Applications of Synthetic and Systems Biology is organized into sections as a topic-by-topic distillation of the presentations and discussions that took place at the workshop. Its purpose is to present information from relevant experience, to delineate a range of pivotal issues and their respective challenges, and to offer differing perspectives on the topic as discussed and described by the workshop participants. This report also includes a collection of individually authored papers and commentary.
Silent Spring
Author: Rachel Carson
Publisher: Houghton Mifflin Harcourt
ISBN: 0618249060
Pages: 378
Year: 2002
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Discusses the reckless annihilation of fish and birds by the use of pesticides and warns of the possible genetic effects on humans.
Regenesis
Author: George M. Church, Ed Regis
Publisher: Basic Books
ISBN: 0465038654
Pages: 304
Year: 2014-04-08
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“Bold and provocative… Regenesis tells of recent advances that may soon yield endless supplies of renewable energy, increased longevity and the return of long-extinct species.”—New Scientist In Regenesis, Harvard biologist George Church and science writer Ed Regis explore the possibilities—and perils—of the emerging field of synthetic biology. Synthetic biology, in which living organisms are selectively altered by modifying substantial portions of their genomes, allows for the creation of entirely new species of organisms. These technologies—far from the out-of-control nightmare depicted in science fiction—have the power to improve human and animal health, increase our intelligence, enhance our memory, and even extend our life span. A breathtaking look at the potential of this world-changing technology, Regenesis is nothing less than a guide to the future of life.
Regulation of Synthetic Biology
Author: Alison McLennan
Publisher: Edward Elgar Publishing
ISBN: 178536944X
Pages: 424
Year: 2018
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This book explores the interplay between regulation and emerging technologies in the context of synthetic biology, a developing field that promises great benefits, and has already yielded fuels and medicines made with designer micro-organisms. For all its promise, however, it also poses various risks. Investigating the distinctiveness of synthetic biology and the regulatory issues that arise, Alison McLennan questions whether synthetic biology can be regulated within existing structures or whether new mechanisms are needed.
Industrialization of Biology
Author: Committee on Industrialization of Biology: A Roadmap to Accelerate the Advanced Manufacturing of Chemicals, Board on Chemical Sciences and Technology, Board on Life Sciences, Division on Earth and Life Studies, National Research Council
Publisher:
ISBN: 0309316529
Pages: 176
Year: 2015-06-29
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The tremendous progress in biology over the last half century - from Watson and Crick's elucidation of the structure of DNA to today's astonishing, rapid progress in the field of synthetic biology - has positioned us for significant innovation in chemical production. New bio-based chemicals, improved public health through improved drugs and diagnostics, and biofuels that reduce our dependency on oil are all results of research and innovation in the biological sciences. In the past decade, we have witnessed major advances made possible by biotechnology in areas such as rapid, low-cost DNA sequencing, metabolic engineering, and high-throughput screening. The manufacturing of chemicals using biological synthesis and engineering could expand even faster. A proactive strategy - implemented through the development of a technical roadmap similar to those that enabled sustained growth in the semiconductor industry and our explorations of space - is needed if we are to realize the widespread benefits of accelerating the industrialization of biology. "Industrialization of Biology" presents such a roadmap to achieve key technical milestones for chemical manufacturing through biological routes. This report examines the technical, economic, and societal factors that limit the adoption of bioprocessing in the chemical industry today and which, if surmounted, would markedly accelerate the advanced manufacturing of chemicals via industrial biotechnology. Working at the interface of synthetic chemistry, metabolic engineering, molecular biology, and synthetic biology, "Industrialization of Biology" identifies key technical goals for next-generation chemical manufacturing, then identifies the gaps in knowledge, tools, techniques, and systems required to meet those goals, and targets and timelines for achieving them. This report also considers the skills necessary to accomplish the roadmap goals, and what training opportunities are required to produce the cadre of skilled scientists and engineers needed.
A New Biology for the 21st Century
Author: National Research Council, Division on Earth and Life Studies, Board on Life Sciences, Committee on a New Biology for the 21st Century: Ensuring the United States Leads the Coming Biology Revolution
Publisher: National Academies Press
ISBN: 0309147867
Pages: 112
Year: 2009-11-20
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Now more than ever, biology has the potential to contribute practical solutions to many of the major challenges confronting the United States and the world. A New Biology for the 21st Century recommends that a "New Biology" approach--one that depends on greater integration within biology, and closer collaboration with physical, computational, and earth scientists, mathematicians and engineers--be used to find solutions to four key societal needs: sustainable food production, ecosystem restoration, optimized biofuel production, and improvement in human health. The approach calls for a coordinated effort to leverage resources across the federal, private, and academic sectors to help meet challenges and improve the return on life science research in general.
BioBuilder
Author: Natalie Kuldell PhD., Rachel Bernstein, Karen Ingram, Kathryn M Hart
Publisher: "O'Reilly Media, Inc."
ISBN: 1491907533
Pages: 238
Year: 2015-06-22
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Today’s synthetic biologists are in the early stages of engineering living cells to help treat diseases, sense toxic compounds in the environment, and produce valuable drugs. With this manual, you can be part of it. Based on the BioBuilder curriculum, this valuable book provides open-access, modular, hands-on lessons in synthetic biology for secondary and post-secondary classrooms and laboratories. It also serves as an introduction to the field for science and engineering enthusiasts. Developed at MIT in collaboration with award-winning high school teachers, BioBuilder teaches the foundational ideas of the emerging synthetic biology field, as well as key aspects of biological engineering that researchers are exploring in labs throughout the world. These lessons will empower teachers and students to explore and be part of solving persistent real-world challenges. Learn the fundamentals of biodesign and DNA engineering Explore important ethical issues raised by examples of synthetic biology Investigate the BioBuilder labs that probe the design-build-test cycle Test synthetic living systems designed and built by engineers Measure several variants of an enzyme-generating genetic circuit Model "bacterial photography" that changes a strain’s light sensitivity Build living systems to produce purple or green pigment Optimize baker’s yeast to produce ?-carotene
The New Science of Metagenomics:
Author: Committee on Metagenomics: Challenges and Functional Applications, Board on Life Sciences, Division on Earth and Life Studies, National Research Council
Publisher: National Academies Press
ISBN: 0309106761
Pages: 170
Year: 2007-05-24
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Although we can't usually see them, microbes are essential for every part of human life -- indeed all life on Earth. The emerging field of metagenomics offers a new way of exploring the microbial world that will transform modern microbiology and lead to practical applications in medicine, agriculture, alternative energy, environmental remediation, and many others areas. Metagenomics allows researchers to look at the genomes of all of the microbes in an environment at once, providing a "meta" view of the whole microbial community and the complex interactions within it. It's a quantum leap beyond traditional research techniques that rely on studying -- one at a time -- the few microbes that can be grown in the laboratory. At the request of the National Science Foundation, five Institutes of the National Institutes of Health, and the Department of Energy, the National Research Council organized a committee to address the current state of metagenomics and identify obstacles current researchers are facing in order to determine how to best support the field and encourage its success. The New Science of Metagenomics recommends the establishment of a "Global Metagenomics Initiative" comprising a small number of large-scale metagenomics projects as well as many medium- and small-scale projects to advance the technology and develop the standard practices needed to advance the field. The report also addresses database needs, methodological challenges, and the importance of interdisciplinary collaboration in supporting this new field.
Applications of Toxicogenomic Technologies to Predictive Toxicology and Risk Assessment
Author: National Research Council, Division on Earth and Life Studies, Board on Life Sciences, Board on Environmental Studies and Toxicology, Committee on Applications of Toxicogenomic Technologies to Predictive Toxicology
Publisher: National Academies Press
ISBN: 0309178894
Pages: 300
Year: 2007-11-19
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The new field of toxicogenomics presents a potentially powerful set of tools to better understand the health effects of exposures to toxicants in the environment. At the request of the National Institute of Environmental Health Sciences, the National Research Council assembled a committee to identify the benefits of toxicogenomics, the challenges to achieving them, and potential approaches to overcoming such challenges. The report concludes that realizing the potential of toxicogenomics to improve public health decisions will require a concerted effort to generate data, make use of existing data, and study data in new ways--an effort requiring funding, interagency coordination, and data management strategies.
Responsible Research with Biological Select Agents and Toxins
Author: Committee on Laboratory Security and Personnel Reliability Assurance Systems for Laboratories Conducting Research on Biological Select Agents and Toxins, Board on Life Sciences, Division on Earth and Life Studies, National Research Council
Publisher: National Academies Press
ISBN: 030914535X
Pages: 188
Year: 2010-01-12
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The effort to understand and combat infectious diseases has, during the centuries, produced many key advances in science and medicine--including the development of vaccines, drugs, and other treatments. A subset of this research is conducted with agents that, like anthrax, not only pose a severe threat to the health of humans, plants, and animals but can also be used for ill-intended purposes. Such agents have been listed by the government as biological select agents and toxins. The 2001 anthrax letter attacks prompted the creation of new regulations aimed at increasing security for research with dangerous pathogens. The outcome of the anthrax letter investigation has raised concern about whether these measures are adequate. Responsible Research with Biological Select Agents and Toxins evaluates both the physical security of select agent laboratories and personnel reliability measures designed to ensure the trustworthiness of those with access to biological select agents and toxins. The book offers a set of guiding principles and recommended changes to minimize security risk and facilitate the productivity of research. The book recommends fostering a culture of trust and responsibility in the laboratory, engaging the community in oversight of the Select Agent Program, and enhancing the operation of the Select Agent Program.