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Toxicological Survey of African Medicinal Plants
Author: Victor Kuete
Publisher: Elsevier
ISBN: 0128004754
Pages: 744
Year: 2014-05-30
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Toxicological Survey of African Medicinal Plants provides a detailed overview of toxicological studies relating to traditionally used medicinal plants in Africa, with special emphasis on the methodologies and tools used for data collection and interpretation. The book considers the physical parameters of these plants and their effect upon various areas of the body and human health, including chapters dedicated to genotoxicity, hepatotoxicity, nephrotoxicity, cardiotoxicity, neurotoxicity, and specific organs and systems. Following this discussion of the effects of medicinal plants is a critical review of the guidelines and methods in use for toxicological research as well as the state of toxicology studies in Africa. With up-to-date research provided by a team of experts, Toxicological Survey of African Medicinal Plants is an invaluable resource for researchers and students involved in pharmacology, toxicology, phytochemistry, medicine, pharmacognosy, and pharmaceutical biology. Offers a critical review of the methods used in toxicological survey of medicinal plants Provides up-to-date toxicological data on African medicinal plants and families Serves as a resource tool for students and scientists in the various areas of toxicology
Bending Science
Author: Thomas O. McGarity, Wendy Elizabeth Wagner
Publisher: Harvard University Press
ISBN: 0674028155
Pages: 384
Year: 2008
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What do we know about the possible poisons that industrial technologies leave in our air and water? How reliable is the science that federal regulators and legislators use to protect the public from dangerous products? As this disturbing book shows, ideological or economic attacks on research are part of an extensive pattern of abuse. Thomas O. McGarity and Wendy Wagner reveal the range of sophisticated legal and financial tactics political and corporate advocates use to discredit or suppress research on potential human health hazards. Scientists can find their research blocked, or find themselves threatened with financial ruin. Corporations, plaintiff attorneys, think tanks, even government agencies have been caught suppressing or distorting research on the safety of chemical products. With alarming stories drawn from the public record, McGarity and Wagner describe how advocates attempt to bend science or âeoespinâe findings. They reveal an immense range of tools available to shrewd partisans determined to manipulate research. Bending Science exposes an astonishing pattern of corruption and makes a compelling case for reforms to safeguard both the integrity of science and the public health.
Strengthening Forensic Science in the United States
Author: National Research Council, Division on Engineering and Physical Sciences, Committee on Applied and Theoretical Statistics, Policy and Global Affairs, Committee on Science, Technology, and Law, Committee on Identifying the Needs of the Forensic Sciences Community
Publisher: National Academies Press
ISBN: 0309142393
Pages: 348
Year: 2009-07-29
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Scores of talented and dedicated people serve the forensic science community, performing vitally important work. However, they are often constrained by lack of adequate resources, sound policies, and national support. It is clear that change and advancements, both systematic and scientific, are needed in a number of forensic science disciplines to ensure the reliability of work, establish enforceable standards, and promote best practices with consistent application. Strengthening Forensic Science in the United States: A Path Forward provides a detailed plan for addressing these needs and suggests the creation of a new government entity, the National Institute of Forensic Science, to establish and enforce standards within the forensic science community. The benefits of improving and regulating the forensic science disciplines are clear: assisting law enforcement officials, enhancing homeland security, and reducing the risk of wrongful conviction and exoneration. Strengthening Forensic Science in the United States gives a full account of what is needed to advance the forensic science disciplines, including upgrading of systems and organizational structures, better training, widespread adoption of uniform and enforceable best practices, and mandatory certification and accreditation programs. While this book provides an essential call-to-action for congress and policy makers, it also serves as a vital tool for law enforcement agencies, criminal prosecutors and attorneys, and forensic science educators.
Criminalistics
Author: Richard Saferstein
Publisher: Pearson
ISBN: 0134477596
Pages: 576
Year: 2017-01-03
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For introductory courses in Forensic Science and Crime Scene Investigation A clear introduction to the technology of the modern crime laboratory for non-scientists Criminalistics: An Introduction to Forensic Science, Twelfth Edition, uses clear writing, case stories, and modern technology to capture the pulse and fervor of forensic science investigations. Written for readers with no scientific background, only the most relevant scientific and technological concepts are presented. The nature of physical evidence is defined, and the limitations that technology and current knowledge impose on its individualization and characterization are examined. A major portion of the text centers on discussions of the common items of physical evidence encountered at crime scenes. Particular attention is paid to the meaning and role of probability in interpreting the evidential significance of scientifically evaluated evidence. Updated throughout, the Twelfth Edition includes a new chapter on the exciting field of forensic biometrics. With its easy-to-understand writing and straightforward presentation, this best-selling text is clear and comprehensible to a wide variety of students.
Only a Theory
Author: Kenneth Raymond Miller
Publisher: Penguin
ISBN: 067001883X
Pages: 244
Year: 2008
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Evaluates the debate between advocates for evolution and intelligent design which occured during the 2005 Dover evolution trial, dissecting the claims of the intelligent design movement and explaining why the conflict is compromising America's position a
Pathology for Toxicologists
Author: Elizabeth McInnes
Publisher: John Wiley & Sons
ISBN: 1118755316
Pages: 216
Year: 2017-03-16
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Non-pathologists, such as toxicologists and study personnel, can find it difficult to understand the data they receive from pathologists. Toxicological pathologists write long, detailed and highly technical reports. Study personnel are under daily pressure to decide whether lesions described in pathology reports are treatment-related and thus important to the pharmaceutical company or whether the lesions are background changes and thus of little significance. Written by experienced toxicological pathologists, Pathology for Toxicologists: Principles and Practices of Laboratory Animal Pathology for Study Personnel serves to bridge the gap in the understanding of pathology data, enabling non-pathologists to more easily comprehend pathology reports, better integrate pathology data into final study reports and ask pathologists relevant questions about the test compound. This succinct, fully referenced, full colour book is suitable for toxicologists at all stages of their training or career who want to know more about the pathology encountered in laboratory animals used in safety studies. Key features include important chapters on spontaneous and target organ lesions in rats, mice, non-human primates, mini pigs, rabbits and beagle dogs as well as information on general pathology, macroscopic target organ lesions, ancillary pathology techniques, haematology, biochemistry and adversity. Pathology for Toxicologists: Principles and Practices of Laboratory Animal Pathology for Study Personnel includes: Colour diagrams explaining how lesions are caused by either external compounds or spontaneously The anatomic variations and background lesions of laboratory animals Advice on sampling tissues, necropsy, ancillary pathology techniques and recording data A chapter on the haematology and biochemistry of laboratory animals Full colour photographs of common macroscopic lesions encountered in laboratory animals A comprehensive glossary
Chemical Pesticides Mode of Action and Toxicology
Author: Jørgen Stenersen
Publisher: CRC Press
ISBN: 0203646835
Pages: 296
Year: 2004-05-27
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Environmental-friendliness, issues of public health, and the pros and cons of genetically-modified crops all receive regular coverage in the world's media. This, in turn, has led to increased questioning and investigation of chemical pesticides. Stenersen's concise and timely introduction to chemical pesticides describes these compounds according to their mode of action at the cellular and biochemical level. Chemical Pesticides provides answers to questions such as why pesticides are toxic to the target organism and why pesticides are toxic to some organisms and not others. It describes how various poisons interfere with biochemical processes in organisms. The book also explores how resistance to pesticides develops, how resistance can be used to illustrate the theory of evolution, and how it can be used to produce herbicide-resistant crop plants. Legal matters and potential environmental problems are also discussed. By providing an integrated, yet simple description of modern chemical pesticides, the author provides a relevant text for professionals and students in biological disciplines such as biochemistry, medicine, agriculture, and veterinary science.
Dictionary of Pharmaceutical Medicine
Author: Gerhard Nahler
Publisher: Springer
ISBN: 3319506692
Pages: 396
Year: 2017-04-15
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This dictionary defines various terms typically used in pharmaceutical medicine. A new, 4th edition includes adaptations of the text to the steadily increasing regulatory requirements, particularly in the area of genetics/gene therapy, product quality (e.g., protection against falsified medicines) and of product safety (pharmacovigilance). Further evolving areas that are covered by the 4th edition are typical “grey zones” (health effects often borderline to medicinal products) such as cosmetics and dietary supplements where misleading information is prohibited on one hand but where any health claims need formal authorisation on the other. These but also other areas are reviewed and presented in an updated and – if justified – in an enlarged form.
Nonclinical Safety Assessment
Author: William J. Brock, Kenneth L. Hastings, Kathy M. McGown
Publisher: John Wiley & Sons
ISBN: 1118516982
Pages: 488
Year: 2013-03-05
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Bringing a new drug to market is a costly time-consuming process. Increased regional and international regulation over the last twenty years, while necessary, has only served to amplify these costs. In response to this escalation, developmental strategies have shifted towards a more global approach. In order to create the most cost-effective and safe processes, it is critical for those bringing drugs to market to understand both the globally accepted regulations and the local variations. Nonclinical Safety Assessment: A Guide to International Pharmaceutical Regulations provides a practical description of nonclinical drug development regulations and requirements in the major market regions. It includes: ICH – the International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use National regulations, including US FDA, Canada, Mercosur and Brazil, South Africa, China, Japan, India and Australia Repeated dose toxicity studies Carcinogenicity; Genotoxicity; Developmental and reproductive toxicology; Immunotoxicology Biotechnology-derived pharmaceuticals Vaccine development Phototoxicity and photocarcinogenicity Degradants, impurities, excipients and metabolites Primarily intended for those professionals actively involved in the nonclinical and clinical development of a pharmaceutical product, including toxicologists, pharmacologists, clinicians and project managers, this book provides a roadmap for successful new drug approval and marketing.
Analysis of Cancer Risks in Populations Near Nuclear Facilities:
Author: Committee on the Analysis of Cancer Risks in Populations near Nuclear Facilities-Phase I, Nuclear and Radiation Studies Board, Division on Earth and Life Studies, National Research Council
Publisher: National Academies Press
ISBN: 0309255716
Pages: 412
Year: 2012-05-29
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In the late 1980s, the National Cancer Institute initiated an investigation of cancer risks in populations near 52 commercial nuclear power plants and 10 Department of Energy nuclear facilities (including research and nuclear weapons production facilities and one reprocessing plant) in the United States. The results of the NCI investigation were used a primary resource for communicating with the public about the cancer risks near the nuclear facilities. However, this study is now over 20 years old. The U.S. Nuclear Regulatory Commission requested that the National Academy of Sciences provide an updated assessment of cancer risks in populations near USNRC-licensed nuclear facilities that utilize or process uranium for the production of electricity. Analysis of Cancer Risks in Populations near Nuclear Facilities: Phase 1 focuses on identifying scientifically sound approaches for carrying out an assessment of cancer risks associated with living near a nuclear facility, judgments about the strengths and weaknesses of various statistical power, ability to assess potential confounding factors, possible biases, and required effort. The results from this Phase 1 study will be used to inform the design of cancer risk assessment, which will be carried out in Phase 2. This report is beneficial for the general public, communities near nuclear facilities, stakeholders, healthcare providers, policy makers, state and local officials, community leaders, and the media.
Reproductive and Developmental Toxicology
Author: Ramesh C. Gupta
Publisher: Academic Press
ISBN: 0128042400
Pages: 1460
Year: 2017-03-24
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Reproductive and Developmental Toxicology, Second Edition, is a comprehensive and authoritative resource that provides the latest literature on this complex subject with a primary focus on three core components—parent, placenta, and fetus—and the continuous changes that occur in each. Enriched with relevant references describing every aspect of reproductive toxicology, this revised and updated resource addresses the totality of the subject, discussing a broad range of topics, including nanoparticles and radiation, gases and solvents, smoking, alcohol and drug abuse, and metals, amongst others. With a special focus on placental toxicity, this book is the only available reference to connect the three key risk stages, also including discussions on reproductive and developmental toxicity in domestic animals, fish, and wildlife. Completely revised and updated to include the most recent developments in the field, the book is an essential resource for advanced students and researchers in toxicology, as well as biologists, pharmacologists, and teratologists from academia, industry, and regulatory agencies. Provides a complete, up-to-date, integrated source of information on the key risk stages during reproduction and development Includes new chapters covering significant developments, such as dose-response assessment for developmental toxicity, juvenile toxicity, and neural tube defects, as well as emerging science, such as stem cell application, toxicoproteomics, metabolomics, endocrine disruption, surveillance and regulatory considerations, and risk assessment Offers diverse and unique in vitro and in vivo toxicity models for reproductive and developmental toxicity testing in a user-friendly format that assists in comparative analysis
Biomarkers and Human Biomonitoring
Author: Lisbeth Knudsen, Domenico Franco Merlo
Publisher: Royal Society of Chemistry
ISBN: 1849733376
Pages: 498
Year: 2011-10-19
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Human biomonitoring has developed from a research tool in occupational and environmental health to identify and quantify exposures to harmful substances in urine and blood. The analytical methods for detection of substances in biological media have considerably improved with smaller detection limits and more precise and specific measurements. Human biomonitoring is a valuable tool in exposure estimation of selected populations and currently used in surveillance programs all over the world. This two volume set provides an overview of current available biomarkers and human biomonitoring programs in environmental health, which is timely given the present debate on adverse health effects from environmental exposures. The books decribe both previous and ongoing studies as well as the newer biomarkers of exposure and effects. Volume one describes current human biomonitoring programs in Germany, Romania, France, Canada, India and Belgium, providing convincing evidence of a global decline in human exposures to lead and increasing concern from exposure to endocrine disruptors and the genotoxic compound. Biomarkers of specific exposures to a wide range of widely used everyday compounds such as phthalates, PFCs, bisphenol A, brominated flame retardants, PAHs, dioxins, mercury and arsenic are also discussed. Volume two decribes human biomonitoing of exposures to environmental tobacco smoke, mycotoxins, physiological stress, hormone activity, oxidative stress and ionizing radiation, as well as effect biomarkers of hemoglobin adducts, germ cells, micronuclei and individual susceptability. The books will be essential reading for toxicologists, environmental scientists and all those working in the safety and risk assessment of chemicals.
Science for Sale
Author: David L. Lewis
Publisher: Skyhorse Publishing, Inc.
ISBN: 1628738723
Pages: 352
Year: 2014-06-03
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When Speaker Newt Gingrich greeted Dr. David Lewis in his office overlooking the National Mall, he looked at Dr. Lewis and said: “You know you’re going to be fired for this, don’t you?” “I know,” Dr. Lewis replied, “I just hope to stay out of prison.” Gingrich had just read Dr. Lewis’s commentary in Nature, titled “EPA Science: Casualty of Election Politics.” Three years later, and thirty years after Dr. Lewis began working at EPA, he was back in Washington to receive a Science Achievement Award from Administrator Carol Browner for his second article in Nature. By then, EPA had transferred Dr. Lewis to the University of Georgia to await termination—the Agency’s only scientist to ever be lead author on papers published in Nature and Lancet. The government hires scientists to support its policies; industry hires them to support its business; and universities hire them to bring in grants that are handed out to support government policies and industry practices. Organizations dealing with scientific integrity are designed only to weed out those who commit fraud behind the backs of the institutions where they work. The greatest threat of all is the purposeful corruption of the scientific enterprise by the institutions themselves. The science they create is often only an illusion, designed to deceive; and the scientists they destroy to protect that illusion are often our best. This book is about both, beginning with Dr. Lewis’s experience, and ending with the story of Dr. Andrew Wakefield.
Thimerosal: Let the Science Speak
Author: Robert F. Kennedy
Publisher: Skyhorse Publishing, Inc.
ISBN: 1634504437
Pages: 500
Year: 2015-09-01
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Over a decade ago, following a sharp rise in developmental disorders such as autism and ADHD, the mercury-containing preservative Thimerosal was widely believed to have been eliminated from vaccine supplies in the US and abroad. However, dangerous quantities of Thimerosal continue to be used, posing a significant threat to public health and leading to a crisis of faith in vaccine safety. In this groundbreaking book, Robert F. Kennedy, Jr., and Dr. Mark Hyman examine the research literature on Thimerosal and make a very clear statement about its potentially dangerous effects. In the past, the CDC, FDA, NIH, and AAP, as well as the US Congress, the American Academy of Family Physicians, the US Department of Agriculture, the European Medicines Agency, and the California Environmental Protection Agency have expressed concerns over the use of Thimerosal in vaccines. But despite the many voices calling for action, the media and policy makers have repeatedly failed to adequately address the issue. Now, with Thimerosal: Let the Science Speak, the goals are to educate parents, doctors, and health policy makers; to eliminate this toxic chemical from the world’s vaccine supplies; to move toward safer alternatives; and to maintain or increase vaccination rates critical to the United States and developing nations. With safer options available, parents shouldn’t have to worry about the devastating effects of vaccinating their children.
Understanding Environmental Pollution
Author: Marquita K. Hill
Publisher: Cambridge University Press
ISBN: 1139486403
Pages:
Year: 2010-04-22
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The third edition of this well-received textbook delivers a concise overview of global and individual environmental pollution for undergraduate courses, presenting students with the tools to assess environmental issues. With more than thirty percent new material, Hill assesses pollution from an international perspective, including air and water pollution, global warming, energy, solid and hazardous waste, and pollution at home. Both the sources and impacts of pollution are addressed, as well as governmental, corporate, and personal responsibility for pollution, and pollution prevention is emphasized throughout. Non-technical language encourages greater understanding of these often complex issues, and thought-provoking 'Delving Deeper' exercises are included, increasing engagement with the text and enabling students to apply what they have learned. A new chapter on the chemistry basics of pollution links to sections on toxicology and risk assessment, helping students understand concerns over chemicals and their regulation. An essential review of environmental pollution for environmental science students.